Correlation between hemoglobin and blood pressure in primary and middle school students in Guangzhou / 中国学校卫生

Objective@#To explore the correlation between hemoglobin and blood pressure.@*Methods@#This study adopted the cross-sectional design method. Participants were recruited from grade 2 in primary school, grade 1 from junior and senior high school taking physical examination, including the hemoglobin test, organized by the Guangzhou Municipal Primary and Secondary School Health and Health Promotion Center from January to December in 2015. Correlation between blood pressure and hemoglobin and determinants of blood pressure were analyzed.@*Results@#A total of 34 752 samples participated including 17 414 boys and 17 338 girls. Hemoglobin was negatively associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) among girls with anemia(P<0.01). Hemoglobin was positively associated with SBP and DBP among boys and girls with normal hemoglobin level(P<0.01). With each tertile increase in blood pressure, hemoglobin level increased by 1 mmHg. Logistic regression analysis showed that compared with peers from same grade with hemoglobin level lower than P25, the risk of suffering from pre-hypertension and hypertension among students from grade 2 with hemoglobin level greater than or equal to P75, and those from junior high and senior high schools with hemoglobin level higher than or equal to P50.@*Conclusion@#Among students without anemia population, a positive correlation between hemoglobin and SBP and DBP is observed.

Observation on therapeutic alliance with UDCA and glucocorticoids in AIH-PBC overlap syndrome / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To observe the efficacy of ursodeoxycholic acid (UDCA) combined with glucocorticoids in the treatment of autoimmune hepatitis-primary biliary cirrhosis (AIH-PBC) overlap syndrome.</p><p><b>METHODS</b>19 patients with AIH-PBC overlap syndrome were divided randomly into two groups: initiate combined group and initiate UDCA-monotherapy group. Biochemical responses and pathological features before and after treatment were analyzed retrospectively with student's t test, Wilcoxon rank sum test and Fisher's exact method.</p><p><b>RESULTS</b>In the initiate combination group, biochemical responses in terms of AIH features (ALT decline to normal, IgG is less than or equal to 16 g/L) and PBC features (ALP decline ≥ 40% or to normal) were achieved. In UDCA-monotherapy group, no statistical difference existed in biochemical responses before adding glucocorticoids, whereas the levels of ALT, AST, GLB and IgG decreased significantly when combined with glucocorticoids. No statistical difference of rates of biochemical responses eixted between the two groups, whereas variance could be seen in different pathological stages. Alleviation of inflammatory infiltration after therapy appeared in 3 patients.</p><p><b>CONCLUSION</b>Combination therapy of UDCA with glucocorticoids could be suitable for AIH-PBC overlap syndrome. Early treatment is of benefit for achieving better biochemical response and pathological improvement.</p>

A two-year follow-up study on the efficacy of ursodeoxycholic acid on primary biliary cirrhosis in different stages / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To assess the therapeutic effect of primary biliary cirrhosis(PBC) in different stages with ursodeoxycholic acid (UDCA).</p><p><b>METHODS</b>91 patients with PBC were divided into 4 periods based on levels of liver test and symptoms. Clinical manifestations, biochemical changes and pathological changes were observed for 2 years on UDCA therapy.</p><p><b>RESULTS</b>The levels of alkaline phosphatase (ALP) and glutamyltranspetidase (GGT) at the second PBC period were declined by 51.9% and 67.3% respectively after a 6-month UDCA therapy. The biochemical responses were 81.25% (Paris criteria) and 93.75% (Barcelona criteria). The levels of ALP and GGT at the third PBC period were declined by 48.8% and 46.6% after 6 months of UDCA therapy, and the biochemical responses were 36.84% (Paris criteria) and 57.89% (Barcelona criteria). Symptoms like fatigue, pruritus and jaundice after UDCA therapy were better than before. Same results also appeared at the fourth period. 11 patients in different periods underwent pathological examinations before and after UDCA therapy and no progression found in the first and the second periods, however difference found in the third and the fourth periods with the lymphocyte infiltration was less than before UDCA treatment.</p><p><b>CONCLUSION</b>Good biochemical responds appear in patients at the second, third and forth periods after UDCA therapy, in which the second period is best. Symptoms could be improved after UDCA treatment. Early UDCA therapy is benefit for slowing down the progression of liver pathology.</p>